// // Variables // -------------------------------------------------- //== Colors // //## Gray and brand colors for use across Bootstrap. @gray-darker: lighten(#000, 13.5%); // #222 @gray-dark: lighten(#000, 20%); // #333 @gray: lighten(#000, 33.5%); // #555 @gray-light: lighten(#000, 60%); // #999 @gray-lighter: lighten(#000, 93.5%); // #eee @brand-primary: #428bca; @brand-success: #5cb85c; @brand-info: #5bc0de; @brand-warning: #f0ad4e; @brand-danger: #d9534f; //== Scaffolding // //## Settings for some of the most global styles. //** Background color for `
`. @body-bg: #fff; //** Global text color on ``. @text-color: @gray-dark; //** Global textual link color. @link-color: @brand-primary; //** Link hover color set via `darken()` function. @link-hover-color: darken(@link-color, 15%); //== Typography // //## Font, line-height, and color for body text, headings, and more. @font-family-sans-serif: "Helvetica Neue", Helvetica, Arial, sans-serif; @font-family-serif: Georgia, "Times New Roman", Times, serif; //** Default monospace fonts for ``, ``, and ``.
@font-family-monospace: Menlo, Monaco, Consolas, "Courier New", monospace;
@font-family-base: @font-family-sans-serif;
@font-size-base: 14px;
@font-size-large: ceil((@font-size-base * 1.25)); // ~18px
@font-size-small: ceil((@font-size-base * 0.85)); // ~12px
@font-size-h1: floor((@font-size-base * 2.6)); // ~36px
@font-size-h2: floor((@font-size-base * 2.15)); // ~30px
@font-size-h3: ceil((@font-size-base * 1.7)); // ~24px
@font-size-h4: ceil((@font-size-base * 1.25)); // ~18px
@font-size-h5: @font-size-base;
@font-size-h6: ceil((@font-size-base * 0.85)); // ~12px
//** Unit-less `line-height` for use in components like buttons.
@line-height-base: 1.428571429; // 20/14
//** Computed "line-height" (`font-size` * `line-height`) for use with `margin`, `padding`, etc.
@line-height-computed: floor((@font-size-base * @line-height-base)); // ~20px
//** By default, this inherits from the ``.
@headings-font-family: inherit;
@headings-font-weight: 500;
@headings-line-height: 1.1;
@headings-color: inherit;
//== Iconography
//
//## Specify custom location and filename of the included Glyphicons icon font. Useful for those including Bootstrap via Bower.
//** Load fonts from this directory.
@icon-font-path: "../fonts/";
//** File name for all font files.
@icon-font-name: "glyphicons-halflings-regular";
//** Element ID within SVG icon file.
@icon-font-svg-id: "glyphicons_halflingsregular";
//== Components
//
//## Define common padding and border radius sizes and more. Values based on 14px text and 1.428 line-height (~20px to start).
@padding-base-vertical: 6px;
@padding-base-horizontal: 12px;
@padding-large-vertical: 10px;
@padding-large-horizontal: 16px;
@padding-small-vertical: 5px;
@padding-small-horizontal: 10px;
@padding-xs-vertical: 1px;
@padding-xs-horizontal: 5px;
@line-height-large: 1.33;
@line-height-small: 1.5;
@border-radius-base: 4px;
@border-radius-large: 6px;
@border-radius-small: 3px;
//** Global color for active items (e.g., navs or dropdowns).
@component-active-color: #fff;
//** Global background color for active items (e.g., navs or dropdowns).
@component-active-bg: @brand-primary;
//** Width of the `border` for generating carets that indicator dropdowns.
@caret-width-base: 4px;
//** Carets increase slightly in size for larger components.
@caret-width-large: 5px;
//== Tables
//
//## Customizes the `.table` component with basic values, each used across all table variations.
//** Padding for ``s and ` `s.
@table-cell-padding: 8px;
//** Padding for cells in `.table-condensed`.
@table-condensed-cell-padding: 5px;
//** Default background color used for all tables.
@table-bg: transparent;
//** Background color used for `.table-striped`.
@table-bg-accent: #f9f9f9;
//** Background color used for `.table-hover`.
@table-bg-hover: #f5f5f5;
@table-bg-active: @table-bg-hover;
//** Border color for table and cell borders.
@table-border-color: #ddd;
//== Buttons
//
//## For each of Bootstrap's buttons, define text, background and border color.
@btn-font-weight: normal;
@btn-default-color: #333;
@btn-default-bg: #fff;
@btn-default-border: #ccc;
@btn-primary-color: #fff;
@btn-primary-bg: @brand-primary;
@btn-primary-border: darken(@btn-primary-bg, 5%);
@btn-success-color: #fff;
@btn-success-bg: @brand-success;
@btn-success-border: darken(@btn-success-bg, 5%);
@btn-info-color: #fff;
@btn-info-bg: @brand-info;
@btn-info-border: darken(@btn-info-bg, 5%);
@btn-warning-color: #fff;
@btn-warning-bg: @brand-warning;
@btn-warning-border: darken(@btn-warning-bg, 5%);
@btn-danger-color: #fff;
@btn-danger-bg: @brand-danger;
@btn-danger-border: darken(@btn-danger-bg, 5%);
@btn-link-disabled-color: @gray-light;
//== Forms
//
//##
//** `` background color
@input-bg: #fff;
//** `` background color
@input-bg-disabled: @gray-lighter;
//** Text color for ``s
@input-color: @gray;
//** `` border color
@input-border: #ccc;
//** `` border radius
@input-border-radius: @border-radius-base;
//** Border color for inputs on focus
@input-border-focus: #66afe9;
//** Placeholder text color
@input-color-placeholder: @gray-light;
//** Default `.form-control` height
@input-height-base: (@line-height-computed + (@padding-base-vertical * 2) + 2);
//** Large `.form-control` height
@input-height-large: (ceil(@font-size-large * @line-height-large) + (@padding-large-vertical * 2) + 2);
//** Small `.form-control` height
@input-height-small: (floor(@font-size-small * @line-height-small) + (@padding-small-vertical * 2) + 2);
@legend-color: @gray-dark;
@legend-border-color: #e5e5e5;
//** Background color for textual input addons
@input-group-addon-bg: @gray-lighter;
//** Border color for textual input addons
@input-group-addon-border-color: @input-border;
//== Dropdowns
//
//## Dropdown menu container and contents.
//** Background for the dropdown menu.
@dropdown-bg: #fff;
//** Dropdown menu `border-color`.
@dropdown-border: rgba(0,0,0,.15);
//** Dropdown menu `border-color` **for IE8**.
@dropdown-fallback-border: #ccc;
//** Divider color for between dropdown items.
@dropdown-divider-bg: #e5e5e5;
//** Dropdown link text color.
@dropdown-link-color: @gray-dark;
//** Hover color for dropdown links.
@dropdown-link-hover-color: darken(@gray-dark, 5%);
//** Hover background for dropdown links.
@dropdown-link-hover-bg: #f5f5f5;
//** Active dropdown menu item text color.
@dropdown-link-active-color: @component-active-color;
//** Active dropdown menu item background color.
@dropdown-link-active-bg: @component-active-bg;
//** Disabled dropdown menu item background color.
@dropdown-link-disabled-color: @gray-light;
//** Text color for headers within dropdown menus.
@dropdown-header-color: @gray-light;
//** Deprecated `@dropdown-caret-color` as of v3.1.0
@dropdown-caret-color: #000;
//-- Z-index master list
//
// Warning: Avoid customizing these values. They're used for a bird's eye view
// of components dependent on the z-axis and are designed to all work together.
//
// Note: These variables are not generated into the Customizer.
@zindex-navbar: 1000;
@zindex-dropdown: 1000;
@zindex-popover: 1060;
@zindex-tooltip: 1070;
@zindex-navbar-fixed: 1030;
@zindex-modal-background: 1040;
@zindex-modal: 1050;
//== Media queries breakpoints
//
//## Define the breakpoints at which your layout will change, adapting to different screen sizes.
// Extra small screen / phone
//** Deprecated `@screen-xs` as of v3.0.1
@screen-xs: 480px;
//** Deprecated `@screen-xs-min` as of v3.2.0
@screen-xs-min: @screen-xs;
//** Deprecated `@screen-phone` as of v3.0.1
@screen-phone: @screen-xs-min;
// Small screen / tablet
//** Deprecated `@screen-sm` as of v3.0.1
@screen-sm: 768px;
@screen-sm-min: @screen-sm;
//** Deprecated `@screen-tablet` as of v3.0.1
@screen-tablet: @screen-sm-min;
// Medium screen / desktop
//** Deprecated `@screen-md` as of v3.0.1
@screen-md: 992px;
@screen-md-min: @screen-md;
//** Deprecated `@screen-desktop` as of v3.0.1
@screen-desktop: @screen-md-min;
// Large screen / wide desktop
//** Deprecated `@screen-lg` as of v3.0.1
@screen-lg: 1200px;
@screen-lg-min: @screen-lg;
//** Deprecated `@screen-lg-desktop` as of v3.0.1
@screen-lg-desktop: @screen-lg-min;
// So media queries don't overlap when required, provide a maximum
@screen-xs-max: (@screen-sm-min - 1);
@screen-sm-max: (@screen-md-min - 1);
@screen-md-max: (@screen-lg-min - 1);
//== Grid system
//
//## Define your custom responsive grid.
//** Number of columns in the grid.
@grid-columns: 12;
//** Padding between columns. Gets divided in half for the left and right.
@grid-gutter-width: 30px;
// Navbar collapse
//** Point at which the navbar becomes uncollapsed.
@grid-float-breakpoint: @screen-sm-min;
//** Point at which the navbar begins collapsing.
@grid-float-breakpoint-max: (@grid-float-breakpoint - 1);
//== Container sizes
//
//## Define the maximum width of `.container` for different screen sizes.
// Small screen / tablet
@container-tablet: ((720px + @grid-gutter-width));
//** For `@screen-sm-min` and up.
@container-sm: @container-tablet;
// Medium screen / desktop
@container-desktop: ((940px + @grid-gutter-width));
//** For `@screen-md-min` and up.
@container-md: @container-desktop;
// Large screen / wide desktop
@container-large-desktop: ((1140px + @grid-gutter-width));
//** For `@screen-lg-min` and up.
@container-lg: @container-large-desktop;
//== Navbar
//
//##
// Basics of a navbar
@navbar-height: 50px;
@navbar-margin-bottom: @line-height-computed;
@navbar-border-radius: @border-radius-base;
@navbar-padding-horizontal: floor((@grid-gutter-width / 2));
@navbar-padding-vertical: ((@navbar-height - @line-height-computed) / 2);
@navbar-collapse-max-height: 340px;
@navbar-default-color: #777;
@navbar-default-bg: #f8f8f8;
@navbar-default-border: darken(@navbar-default-bg, 6.5%);
// Navbar links
@navbar-default-link-color: #777;
@navbar-default-link-hover-color: #333;
@navbar-default-link-hover-bg: transparent;
@navbar-default-link-active-color: #555;
@navbar-default-link-active-bg: darken(@navbar-default-bg, 6.5%);
@navbar-default-link-disabled-color: #ccc;
@navbar-default-link-disabled-bg: transparent;
// Navbar brand label
@navbar-default-brand-color: @navbar-default-link-color;
@navbar-default-brand-hover-color: darken(@navbar-default-brand-color, 10%);
@navbar-default-brand-hover-bg: transparent;
// Navbar toggle
@navbar-default-toggle-hover-bg: #ddd;
@navbar-default-toggle-icon-bar-bg: #888;
@navbar-default-toggle-border-color: #ddd;
// Inverted navbar
// Reset inverted navbar basics
@navbar-inverse-color: @gray-light;
@navbar-inverse-bg: #222;
@navbar-inverse-border: darken(@navbar-inverse-bg, 10%);
// Inverted navbar links
@navbar-inverse-link-color: @gray-light;
@navbar-inverse-link-hover-color: #fff;
@navbar-inverse-link-hover-bg: transparent;
@navbar-inverse-link-active-color: @navbar-inverse-link-hover-color;
@navbar-inverse-link-active-bg: darken(@navbar-inverse-bg, 10%);
@navbar-inverse-link-disabled-color: #444;
@navbar-inverse-link-disabled-bg: transparent;
// Inverted navbar brand label
@navbar-inverse-brand-color: @navbar-inverse-link-color;
@navbar-inverse-brand-hover-color: #fff;
@navbar-inverse-brand-hover-bg: transparent;
// Inverted navbar toggle
@navbar-inverse-toggle-hover-bg: #333;
@navbar-inverse-toggle-icon-bar-bg: #fff;
@navbar-inverse-toggle-border-color: #333;
//== Navs
//
//##
//=== Shared nav styles
@nav-link-padding: 10px 15px;
@nav-link-hover-bg: @gray-lighter;
@nav-disabled-link-color: @gray-light;
@nav-disabled-link-hover-color: @gray-light;
@nav-open-link-hover-color: #fff;
//== Tabs
@nav-tabs-border-color: #ddd;
@nav-tabs-link-hover-border-color: @gray-lighter;
@nav-tabs-active-link-hover-bg: @body-bg;
@nav-tabs-active-link-hover-color: @gray;
@nav-tabs-active-link-hover-border-color: #ddd;
@nav-tabs-justified-link-border-color: #ddd;
@nav-tabs-justified-active-link-border-color: @body-bg;
//== Pills
@nav-pills-border-radius: @border-radius-base;
@nav-pills-active-link-hover-bg: @component-active-bg;
@nav-pills-active-link-hover-color: @component-active-color;
//== Pagination
//
//##
@pagination-color: @link-color;
@pagination-bg: #fff;
@pagination-border: #ddd;
@pagination-hover-color: @link-hover-color;
@pagination-hover-bg: @gray-lighter;
@pagination-hover-border: #ddd;
@pagination-active-color: #fff;
@pagination-active-bg: @brand-primary;
@pagination-active-border: @brand-primary;
@pagination-disabled-color: @gray-light;
@pagination-disabled-bg: #fff;
@pagination-disabled-border: #ddd;
//== Pager
//
//##
@pager-bg: @pagination-bg;
@pager-border: @pagination-border;
@pager-border-radius: 15px;
@pager-hover-bg: @pagination-hover-bg;
@pager-active-bg: @pagination-active-bg;
@pager-active-color: @pagination-active-color;
@pager-disabled-color: @pagination-disabled-color;
//== Jumbotron
//
//##
@jumbotron-padding: 30px;
@jumbotron-color: inherit;
@jumbotron-bg: @gray-lighter;
@jumbotron-heading-color: inherit;
@jumbotron-font-size: ceil((@font-size-base * 1.5));
//== Form states and alerts
//
//## Define colors for form feedback states and, by default, alerts.
@state-success-text: #3c763d;
@state-success-bg: #dff0d8;
@state-success-border: darken(spin(@state-success-bg, -10), 5%);
@state-info-text: #31708f;
@state-info-bg: #d9edf7;
@state-info-border: darken(spin(@state-info-bg, -10), 7%);
@state-warning-text: #8a6d3b;
@state-warning-bg: #fcf8e3;
@state-warning-border: darken(spin(@state-warning-bg, -10), 5%);
@state-danger-text: #a94442;
@state-danger-bg: #f2dede;
@state-danger-border: darken(spin(@state-danger-bg, -10), 5%);
//== Tooltips
//
//##
//** Tooltip max width
@tooltip-max-width: 200px;
//** Tooltip text color
@tooltip-color: #fff;
//** Tooltip background color
@tooltip-bg: #000;
@tooltip-opacity: .9;
//** Tooltip arrow width
@tooltip-arrow-width: 5px;
//** Tooltip arrow color
@tooltip-arrow-color: @tooltip-bg;
//== Popovers
//
//##
//** Popover body background color
@popover-bg: #fff;
//** Popover maximum width
@popover-max-width: 276px;
//** Popover border color
@popover-border-color: rgba(0,0,0,.2);
//** Popover fallback border color
@popover-fallback-border-color: #ccc;
//** Popover title background color
@popover-title-bg: darken(@popover-bg, 3%);
//** Popover arrow width
@popover-arrow-width: 10px;
//** Popover arrow color
@popover-arrow-color: #fff;
//** Popover outer arrow width
@popover-arrow-outer-width: (@popover-arrow-width + 1);
//** Popover outer arrow color
@popover-arrow-outer-color: fadein(@popover-border-color, 5%);
//** Popover outer arrow fallback color
@popover-arrow-outer-fallback-color: darken(@popover-fallback-border-color, 20%);
//== Labels
//
//##
//** Default label background color
@label-default-bg: @gray-light;
//** Primary label background color
@label-primary-bg: @brand-primary;
//** Success label background color
@label-success-bg: @brand-success;
//** Info label background color
@label-info-bg: @brand-info;
//** Warning label background color
@label-warning-bg: @brand-warning;
//** Danger label background color
@label-danger-bg: @brand-danger;
//** Default label text color
@label-color: #fff;
//** Default text color of a linked label
@label-link-hover-color: #fff;
//== Modals
//
//##
//** Padding applied to the modal body
@modal-inner-padding: 15px;
//** Padding applied to the modal title
@modal-title-padding: 15px;
//** Modal title line-height
@modal-title-line-height: @line-height-base;
//** Background color of modal content area
@modal-content-bg: #fff;
//** Modal content border color
@modal-content-border-color: rgba(0,0,0,.2);
//** Modal content border color **for IE8**
@modal-content-fallback-border-color: #999;
//** Modal backdrop background color
@modal-backdrop-bg: #000;
//** Modal backdrop opacity
@modal-backdrop-opacity: .5;
//** Modal header border color
@modal-header-border-color: #e5e5e5;
//** Modal footer border color
@modal-footer-border-color: @modal-header-border-color;
@modal-lg: 900px;
@modal-md: 600px;
@modal-sm: 300px;
//== Alerts
//
//## Define alert colors, border radius, and padding.
@alert-padding: 15px;
@alert-border-radius: @border-radius-base;
@alert-link-font-weight: bold;
@alert-success-bg: @state-success-bg;
@alert-success-text: @state-success-text;
@alert-success-border: @state-success-border;
@alert-info-bg: @state-info-bg;
@alert-info-text: @state-info-text;
@alert-info-border: @state-info-border;
@alert-warning-bg: @state-warning-bg;
@alert-warning-text: @state-warning-text;
@alert-warning-border: @state-warning-border;
@alert-danger-bg: @state-danger-bg;
@alert-danger-text: @state-danger-text;
@alert-danger-border: @state-danger-border;
//== Progress bars
//
//##
//** Background color of the whole progress component
@progress-bg: #f5f5f5;
//** Progress bar text color
@progress-bar-color: #fff;
//** Default progress bar color
@progress-bar-bg: @brand-primary;
//** Success progress bar color
@progress-bar-success-bg: @brand-success;
//** Warning progress bar color
@progress-bar-warning-bg: @brand-warning;
//** Danger progress bar color
@progress-bar-danger-bg: @brand-danger;
//** Info progress bar color
@progress-bar-info-bg: @brand-info;
//== List group
//
//##
//** Background color on `.list-group-item`
@list-group-bg: #fff;
//** `.list-group-item` border color
@list-group-border: #ddd;
//** List group border radius
@list-group-border-radius: @border-radius-base;
//** Background color of single list items on hover
@list-group-hover-bg: #f5f5f5;
//** Text color of active list items
@list-group-active-color: @component-active-color;
//** Background color of active list items
@list-group-active-bg: @component-active-bg;
//** Border color of active list elements
@list-group-active-border: @list-group-active-bg;
//** Text color for content within active list items
@list-group-active-text-color: lighten(@list-group-active-bg, 40%);
//** Text color of disabled list items
@list-group-disabled-color: @gray-light;
//** Background color of disabled list items
@list-group-disabled-bg: @gray-lighter;
//** Text color for content within disabled list items
@list-group-disabled-text-color: @list-group-disabled-color;
@list-group-link-color: #555;
@list-group-link-hover-color: @list-group-link-color;
@list-group-link-heading-color: #333;
//== Panels
//
//##
@panel-bg: #fff;
@panel-body-padding: 15px;
@panel-heading-padding: 10px 15px;
@panel-footer-padding: @panel-heading-padding;
@panel-border-radius: @border-radius-base;
//** Border color for elements within panels
@panel-inner-border: #ddd;
@panel-footer-bg: #f5f5f5;
@panel-default-text: @gray-dark;
@panel-default-border: #ddd;
@panel-default-heading-bg: #f5f5f5;
@panel-primary-text: #fff;
@panel-primary-border: @brand-primary;
@panel-primary-heading-bg: @brand-primary;
@panel-success-text: @state-success-text;
@panel-success-border: @state-success-border;
@panel-success-heading-bg: @state-success-bg;
@panel-info-text: @state-info-text;
@panel-info-border: @state-info-border;
@panel-info-heading-bg: @state-info-bg;
@panel-warning-text: @state-warning-text;
@panel-warning-border: @state-warning-border;
@panel-warning-heading-bg: @state-warning-bg;
@panel-danger-text: @state-danger-text;
@panel-danger-border: @state-danger-border;
@panel-danger-heading-bg: @state-danger-bg;
//== Thumbnails
//
//##
//** Padding around the thumbnail image
@thumbnail-padding: 4px;
//** Thumbnail background color
@thumbnail-bg: @body-bg;
//** Thumbnail border color
@thumbnail-border: #ddd;
//** Thumbnail border radius
@thumbnail-border-radius: @border-radius-base;
//** Custom text color for thumbnail captions
@thumbnail-caption-color: @text-color;
//** Padding around the thumbnail caption
@thumbnail-caption-padding: 9px;
//== Wells
//
//##
@well-bg: #f5f5f5;
@well-border: darken(@well-bg, 7%);
//== Badges
//
//##
@badge-color: #fff;
//** Linked badge text color on hover
@badge-link-hover-color: #fff;
@badge-bg: @gray-light;
//** Badge text color in active nav link
@badge-active-color: @link-color;
//** Badge background color in active nav link
@badge-active-bg: #fff;
@badge-font-weight: bold;
@badge-line-height: 1;
@badge-border-radius: 10px;
//== Breadcrumbs
//
//##
@breadcrumb-padding-vertical: 8px;
@breadcrumb-padding-horizontal: 15px;
//** Breadcrumb background color
@breadcrumb-bg: #f5f5f5;
//** Breadcrumb text color
@breadcrumb-color: #ccc;
//** Text color of current page in the breadcrumb
@breadcrumb-active-color: @gray-light;
//** Textual separator for between breadcrumb elements
@breadcrumb-separator: "/";
//== Carousel
//
//##
@carousel-text-shadow: 0 1px 2px rgba(0,0,0,.6);
@carousel-control-color: #fff;
@carousel-control-width: 15%;
@carousel-control-opacity: .5;
@carousel-control-font-size: 20px;
@carousel-indicator-active-bg: #fff;
@carousel-indicator-border-color: #fff;
@carousel-caption-color: #fff;
//== Close
//
//##
@close-font-weight: bold;
@close-color: #000;
@close-text-shadow: 0 1px 0 #fff;
//== Code
//
//##
@code-color: #c7254e;
@code-bg: #f9f2f4;
@kbd-color: #fff;
@kbd-bg: #333;
@pre-bg: #f5f5f5;
@pre-color: @gray-dark;
@pre-border-color: #ccc;
@pre-scrollable-max-height: 340px;
//== Type
//
//##
//** Text muted color
@text-muted: @gray-light;
//** Abbreviations and acronyms border color
@abbr-border-color: @gray-light;
//** Headings small color
@headings-small-color: @gray-light;
//** Blockquote small color
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{"id":13012,"date":"2024-08-15T16:17:25","date_gmt":"2024-08-15T10:47:25","guid":{"rendered":"https:\/\/jnpsrilanka.lk\/?p=13012"},"modified":"2024-08-30T16:10:20","modified_gmt":"2024-08-30T10:40:20","slug":"rsum-des-caractristiques-du-produit-tamoxifene-17","status":"publish","type":"post","link":"https:\/\/jnpsrilanka.lk\/rsum-des-caractristiques-du-produit-tamoxifene-17\/","title":{"rendered":"R\ufffdsum\ufffd des caract\ufffdristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim\ufffd"},"content":{"rendered":"R\ufffdsum\ufffd des caract\ufffdristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim\ufffd<\/h1>\n
Il s’utilise en association avec d’autres m\u00e9dicaments pour traiter un cancer du sein au stade pr\u00e9coce. Il sert \u00e9galement \u00e0 traiter le cancer du sein qui a atteint un stade avanc\u00e9 ou qui s’est propag\u00e9 \u00e0 d’autres parties du corps. Entre les diff\u00e9rents anti-aromatases, les chercheurs observent peu de diff\u00e9rence d’efficacit\u00e9. Avec l\u2019anastrozole, le taux de survie sans r\u00e9cidive apr\u00e8s 5 ans est de 90%, de 88% avec l\u2019ex\u00e9mestane, et de 89,4% avec le l\u00e9trozole.<\/p>\n
\n- L’\u00e9paisseur endom\u00e9triale des patientes sous raloxif\u00e8ne n’\u00e9tait pas diff\u00e9rente de celle des patientes sous placebo.<\/li>\n
- Informez votre m\u00e9decin si vous prenez par ailleurs des anticoagulants oraux.<\/li>\n
- Des donn\u00e9es sugg\u00e8rent que le r\u00e9cepteur aux oestrog\u00e8nes peut r\u00e9guler l’expression g\u00e9nique par au moins deux voies distinctes qui sont sp\u00e9cifiques au ligand, au tissu et\/ou au g\u00e8ne.<\/li>\n<\/ul>\n
Effets secondaires du tamoxif\u00e8ne<\/h2>\n
Une prise en charge sp\u00e9cialis\u00e9e en oncologie, par exemple dans un centre de sant\u00e9 int\u00e9grative, avec un parcours de soin adapt\u00e9 peut permettre de diminuer tous ces effets ind\u00e9sirables, d\u2019am\u00e9liorer la qualit\u00e9 de vie et de maintenir une bonne observance du traitement. Cet \u00e9v\u00e8nement ind\u00e9sirable \u00e9tait plus fr\u00e9quent au cours des six premiers mois de traitement et survenait rarement de novo apr\u00e8s cette p\u00e9riode. https:\/\/theroyalpets.com\/steroid-68\/steroides-pour-la-musculation-un-guide-approfondi\/<\/a> Le statut du polymorphisme CYP2D6 peut \u00eatre associ\u00e9 \u00e0 une variabilit\u00e9 de la r\u00e9ponse clinique au tamoxif\u00e8ne. Les donn\ufffdes cliniques disponibles sugg\ufffdrent que les patients qui sont homozygotes pour les all\ufffdles CYP2D6 non-fonctionnelles, peuvent pr\ufffdsenter une diminution de l’effet du tamoxif\ufffdne dans le traitement du cancer du sein. Les \ufffdtudes disponibles ont principalement \ufffdt\ufffd r\ufffdalis\ufffdes chez des femmes m\ufffdnopaus\ufffdes (voir les rubriques 4.4 et 5.2). Comme pour tous les traitements, l\u2019hormonoth\u00e9rapie peut induire des effets secondaires.<\/p>\nPrendre RDV<\/h3>\n
Environ \u00e9chographies transvaginales (ETV) ont \u00e9t\u00e9 \u00e9valu\u00e9es chez 831 patientes, tous groupes confondus. L’\u00e9paisseur endom\u00e9triale des patientes sous raloxif\u00e8ne n’\u00e9tait pas diff\u00e9rente de celle des patientes sous placebo. Apr\u00e8s 3 ans de traitement, une augmentation de l’\u00e9paisseur endom\u00e9triale d’au moins 5 mm \u00e9valu\u00e9e par \u00e9chographie transvaginale, a \u00e9t\u00e9 observ\u00e9e chez 1,9 % des 211 femmes trait\u00e9es par raloxif\u00e8ne 60 mg\/jour en comparaison aux 1,8 % des 219 femmes sous placebo.<\/p>\n
Beipackzettel von TAMOXIFEN-ratiopharm 20 mg Tabletten<\/h2>\n
Le tamoxif\ufffdne est principalement m\ufffdtabolis\ufffd par le CYP3A4 en N-desm\ufffdthyl-tamoxif\ufffdne, qui est ensuite m\ufffdtabolis\ufffd par le CYP2D6 en un autre m\ufffdtabolite actif l’endoxif\ufffdne. Chez les patientes qui n’ont pas l’enzyme CYP2D6, les concentrations d’endoxif\ufffdne sont inf\ufffdrieures d’approximativement 75 % en comparaison aux patientes ayant une activit\ufffd CYP2D6 normale. L’administration d’inhibiteurs puissants du CYP2D6 r\ufffdduit les taux d’endoxif\ufffdne circulant \ufffd un niveau similaire. Chez les patients pr\ufffdsentant un angi\ufffdd\ufffdme h\ufffdr\ufffdditaire, le tamoxif\ufffdne peut provoquer ou aggraver les sympt\ufffdmes d\ufffdangi\ufffdd\ufffdme. Le raloxif\u00e8ne et les oestrog\u00e8nes ont un effet similaire sur le remodelage osseux et sur le m\u00e9tabolisme calcique. Le raloxif\u00e8ne est associ\u00e9 \u00e0 une r\u00e9duction de la r\u00e9sorption osseuse et \u00e0 un d\u00e9placement positif de la valeur moyenne de la balance calcique de 60 mg par jour, d\u00fb principalement \u00e0 une diminution des pertes calciques urinaires.<\/p>\n
Si cela vous int\u00e9resse, vous pouvez consulter la fiche du tamoxif\u00e8ne sur le site de la Haute Autorit\u00e9 de Sant\u00e9. Il faut conserver les comprim\u00e9s dans leur emballage d\u2019origine, \u00e0 temp\u00e9rature ambiante, hors de port\u00e9e des enfants et animaux domestiques. Anomalie de la num\u00e9ration formule sanguine, augmentation des transaminases.<\/p>\n<\/a><\/a><\/a><\/a><\/a><\/a>","protected":false},"excerpt":{"rendered":"R\ufffdsum\ufffd des caract\ufffdristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim\ufffd Il s’utilise en association avec d’autres m\u00e9dicaments pour traiter un […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[22],"tags":[],"class_list":["post-13012","post","type-post","status-publish","format-standard","hentry","category-steroid","cat-22-id"],"yoast_head":"\n
R\ufffdsum\ufffd des caract\ufffdristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim\ufffd | JNP Sri Lanka | National Freedom Front<\/title>\n\n\n\n\n\n\n\n\n\n\n\n\t\n\t\n\t\n\n\n\n\t\n\t\n\t\n