// // Variables // -------------------------------------------------- //== Colors // //## Gray and brand colors for use across Bootstrap. @gray-darker: lighten(#000, 13.5%); // #222 @gray-dark: lighten(#000, 20%); // #333 @gray: lighten(#000, 33.5%); // #555 @gray-light: lighten(#000, 60%); // #999 @gray-lighter: lighten(#000, 93.5%); // #eee @brand-primary: #428bca; @brand-success: #5cb85c; @brand-info: #5bc0de; @brand-warning: #f0ad4e; @brand-danger: #d9534f; //== Scaffolding // //## Settings for some of the most global styles. //** Background color for ``. @body-bg: #fff; //** Global text color on ``. @text-color: @gray-dark; //** Global textual link color. @link-color: @brand-primary; //** Link hover color set via `darken()` function. @link-hover-color: darken(@link-color, 15%); //== Typography // //## Font, line-height, and color for body text, headings, and more. @font-family-sans-serif: "Helvetica Neue", Helvetica, Arial, sans-serif; @font-family-serif: Georgia, "Times New Roman", Times, serif; //** Default monospace fonts for ``, ``, and `
`.
@font-family-monospace:   Menlo, Monaco, Consolas, "Courier New", monospace;
@font-family-base:        @font-family-sans-serif;

@font-size-base:          14px;
@font-size-large:         ceil((@font-size-base * 1.25)); // ~18px
@font-size-small:         ceil((@font-size-base * 0.85)); // ~12px

@font-size-h1:            floor((@font-size-base * 2.6)); // ~36px
@font-size-h2:            floor((@font-size-base * 2.15)); // ~30px
@font-size-h3:            ceil((@font-size-base * 1.7)); // ~24px
@font-size-h4:            ceil((@font-size-base * 1.25)); // ~18px
@font-size-h5:            @font-size-base;
@font-size-h6:            ceil((@font-size-base * 0.85)); // ~12px

//** Unit-less `line-height` for use in components like buttons.
@line-height-base:        1.428571429; // 20/14
//** Computed "line-height" (`font-size` * `line-height`) for use with `margin`, `padding`, etc.
@line-height-computed:    floor((@font-size-base * @line-height-base)); // ~20px

//** By default, this inherits from the ``.
@headings-font-family:    inherit;
@headings-font-weight:    500;
@headings-line-height:    1.1;
@headings-color:          inherit;


//== Iconography
//
//## Specify custom location and filename of the included Glyphicons icon font. Useful for those including Bootstrap via Bower.

//** Load fonts from this directory.
@icon-font-path:          "../fonts/";
//** File name for all font files.
@icon-font-name:          "glyphicons-halflings-regular";
//** Element ID within SVG icon file.
@icon-font-svg-id:        "glyphicons_halflingsregular";


//== Components
//
//## Define common padding and border radius sizes and more. Values based on 14px text and 1.428 line-height (~20px to start).

@padding-base-vertical:     6px;
@padding-base-horizontal:   12px;

@padding-large-vertical:    10px;
@padding-large-horizontal:  16px;

@padding-small-vertical:    5px;
@padding-small-horizontal:  10px;

@padding-xs-vertical:       1px;
@padding-xs-horizontal:     5px;

@line-height-large:         1.33;
@line-height-small:         1.5;

@border-radius-base:        4px;
@border-radius-large:       6px;
@border-radius-small:       3px;

//** Global color for active items (e.g., navs or dropdowns).
@component-active-color:    #fff;
//** Global background color for active items (e.g., navs or dropdowns).
@component-active-bg:       @brand-primary;

//** Width of the `border` for generating carets that indicator dropdowns.
@caret-width-base:          4px;
//** Carets increase slightly in size for larger components.
@caret-width-large:         5px;


//== Tables
//
//## Customizes the `.table` component with basic values, each used across all table variations.

//** Padding for ``s and ``s.
@table-cell-padding:            8px;
//** Padding for cells in `.table-condensed`.
@table-condensed-cell-padding:  5px;

//** Default background color used for all tables.
@table-bg:                      transparent;
//** Background color used for `.table-striped`.
@table-bg-accent:               #f9f9f9;
//** Background color used for `.table-hover`.
@table-bg-hover:                #f5f5f5;
@table-bg-active:               @table-bg-hover;

//** Border color for table and cell borders.
@table-border-color:            #ddd;


//== Buttons
//
//## For each of Bootstrap's buttons, define text, background and border color.

@btn-font-weight:                normal;

@btn-default-color:              #333;
@btn-default-bg:                 #fff;
@btn-default-border:             #ccc;

@btn-primary-color:              #fff;
@btn-primary-bg:                 @brand-primary;
@btn-primary-border:             darken(@btn-primary-bg, 5%);

@btn-success-color:              #fff;
@btn-success-bg:                 @brand-success;
@btn-success-border:             darken(@btn-success-bg, 5%);

@btn-info-color:                 #fff;
@btn-info-bg:                    @brand-info;
@btn-info-border:                darken(@btn-info-bg, 5%);

@btn-warning-color:              #fff;
@btn-warning-bg:                 @brand-warning;
@btn-warning-border:             darken(@btn-warning-bg, 5%);

@btn-danger-color:               #fff;
@btn-danger-bg:                  @brand-danger;
@btn-danger-border:              darken(@btn-danger-bg, 5%);

@btn-link-disabled-color:        @gray-light;


//== Forms
//
//##

//** `` background color
@input-bg:                       #fff;
//** `` background color
@input-bg-disabled:              @gray-lighter;

//** Text color for ``s
@input-color:                    @gray;
//** `` border color
@input-border:                   #ccc;
//** `` border radius
@input-border-radius:            @border-radius-base;
//** Border color for inputs on focus
@input-border-focus:             #66afe9;

//** Placeholder text color
@input-color-placeholder:        @gray-light;

//** Default `.form-control` height
@input-height-base:              (@line-height-computed + (@padding-base-vertical * 2) + 2);
//** Large `.form-control` height
@input-height-large:             (ceil(@font-size-large * @line-height-large) + (@padding-large-vertical * 2) + 2);
//** Small `.form-control` height
@input-height-small:             (floor(@font-size-small * @line-height-small) + (@padding-small-vertical * 2) + 2);

@legend-color:                   @gray-dark;
@legend-border-color:            #e5e5e5;

//** Background color for textual input addons
@input-group-addon-bg:           @gray-lighter;
//** Border color for textual input addons
@input-group-addon-border-color: @input-border;


//== Dropdowns
//
//## Dropdown menu container and contents.

//** Background for the dropdown menu.
@dropdown-bg:                    #fff;
//** Dropdown menu `border-color`.
@dropdown-border:                rgba(0,0,0,.15);
//** Dropdown menu `border-color` **for IE8**.
@dropdown-fallback-border:       #ccc;
//** Divider color for between dropdown items.
@dropdown-divider-bg:            #e5e5e5;

//** Dropdown link text color.
@dropdown-link-color:            @gray-dark;
//** Hover color for dropdown links.
@dropdown-link-hover-color:      darken(@gray-dark, 5%);
//** Hover background for dropdown links.
@dropdown-link-hover-bg:         #f5f5f5;

//** Active dropdown menu item text color.
@dropdown-link-active-color:     @component-active-color;
//** Active dropdown menu item background color.
@dropdown-link-active-bg:        @component-active-bg;

//** Disabled dropdown menu item background color.
@dropdown-link-disabled-color:   @gray-light;

//** Text color for headers within dropdown menus.
@dropdown-header-color:          @gray-light;

//** Deprecated `@dropdown-caret-color` as of v3.1.0
@dropdown-caret-color:           #000;


//-- Z-index master list
//
// Warning: Avoid customizing these values. They're used for a bird's eye view
// of components dependent on the z-axis and are designed to all work together.
//
// Note: These variables are not generated into the Customizer.

@zindex-navbar:            1000;
@zindex-dropdown:          1000;
@zindex-popover:           1060;
@zindex-tooltip:           1070;
@zindex-navbar-fixed:      1030;
@zindex-modal-background:  1040;
@zindex-modal:             1050;


//== Media queries breakpoints
//
//## Define the breakpoints at which your layout will change, adapting to different screen sizes.

// Extra small screen / phone
//** Deprecated `@screen-xs` as of v3.0.1
@screen-xs:                  480px;
//** Deprecated `@screen-xs-min` as of v3.2.0
@screen-xs-min:              @screen-xs;
//** Deprecated `@screen-phone` as of v3.0.1
@screen-phone:               @screen-xs-min;

// Small screen / tablet
//** Deprecated `@screen-sm` as of v3.0.1
@screen-sm:                  768px;
@screen-sm-min:              @screen-sm;
//** Deprecated `@screen-tablet` as of v3.0.1
@screen-tablet:              @screen-sm-min;

// Medium screen / desktop
//** Deprecated `@screen-md` as of v3.0.1
@screen-md:                  992px;
@screen-md-min:              @screen-md;
//** Deprecated `@screen-desktop` as of v3.0.1
@screen-desktop:             @screen-md-min;

// Large screen / wide desktop
//** Deprecated `@screen-lg` as of v3.0.1
@screen-lg:                  1200px;
@screen-lg-min:              @screen-lg;
//** Deprecated `@screen-lg-desktop` as of v3.0.1
@screen-lg-desktop:          @screen-lg-min;

// So media queries don't overlap when required, provide a maximum
@screen-xs-max:              (@screen-sm-min - 1);
@screen-sm-max:              (@screen-md-min - 1);
@screen-md-max:              (@screen-lg-min - 1);


//== Grid system
//
//## Define your custom responsive grid.

//** Number of columns in the grid.
@grid-columns:              12;
//** Padding between columns. Gets divided in half for the left and right.
@grid-gutter-width:         30px;
// Navbar collapse
//** Point at which the navbar becomes uncollapsed.
@grid-float-breakpoint:     @screen-sm-min;
//** Point at which the navbar begins collapsing.
@grid-float-breakpoint-max: (@grid-float-breakpoint - 1);


//== Container sizes
//
//## Define the maximum width of `.container` for different screen sizes.

// Small screen / tablet
@container-tablet:             ((720px + @grid-gutter-width));
//** For `@screen-sm-min` and up.
@container-sm:                 @container-tablet;

// Medium screen / desktop
@container-desktop:            ((940px + @grid-gutter-width));
//** For `@screen-md-min` and up.
@container-md:                 @container-desktop;

// Large screen / wide desktop
@container-large-desktop:      ((1140px + @grid-gutter-width));
//** For `@screen-lg-min` and up.
@container-lg:                 @container-large-desktop;


//== Navbar
//
//##

// Basics of a navbar
@navbar-height:                    50px;
@navbar-margin-bottom:             @line-height-computed;
@navbar-border-radius:             @border-radius-base;
@navbar-padding-horizontal:        floor((@grid-gutter-width / 2));
@navbar-padding-vertical:          ((@navbar-height - @line-height-computed) / 2);
@navbar-collapse-max-height:       340px;

@navbar-default-color:             #777;
@navbar-default-bg:                #f8f8f8;
@navbar-default-border:            darken(@navbar-default-bg, 6.5%);

// Navbar links
@navbar-default-link-color:                #777;
@navbar-default-link-hover-color:          #333;
@navbar-default-link-hover-bg:             transparent;
@navbar-default-link-active-color:         #555;
@navbar-default-link-active-bg:            darken(@navbar-default-bg, 6.5%);
@navbar-default-link-disabled-color:       #ccc;
@navbar-default-link-disabled-bg:          transparent;

// Navbar brand label
@navbar-default-brand-color:               @navbar-default-link-color;
@navbar-default-brand-hover-color:         darken(@navbar-default-brand-color, 10%);
@navbar-default-brand-hover-bg:            transparent;

// Navbar toggle
@navbar-default-toggle-hover-bg:           #ddd;
@navbar-default-toggle-icon-bar-bg:        #888;
@navbar-default-toggle-border-color:       #ddd;


// Inverted navbar
// Reset inverted navbar basics
@navbar-inverse-color:                      @gray-light;
@navbar-inverse-bg:                         #222;
@navbar-inverse-border:                     darken(@navbar-inverse-bg, 10%);

// Inverted navbar links
@navbar-inverse-link-color:                 @gray-light;
@navbar-inverse-link-hover-color:           #fff;
@navbar-inverse-link-hover-bg:              transparent;
@navbar-inverse-link-active-color:          @navbar-inverse-link-hover-color;
@navbar-inverse-link-active-bg:             darken(@navbar-inverse-bg, 10%);
@navbar-inverse-link-disabled-color:        #444;
@navbar-inverse-link-disabled-bg:           transparent;

// Inverted navbar brand label
@navbar-inverse-brand-color:                @navbar-inverse-link-color;
@navbar-inverse-brand-hover-color:          #fff;
@navbar-inverse-brand-hover-bg:             transparent;

// Inverted navbar toggle
@navbar-inverse-toggle-hover-bg:            #333;
@navbar-inverse-toggle-icon-bar-bg:         #fff;
@navbar-inverse-toggle-border-color:        #333;


//== Navs
//
//##

//=== Shared nav styles
@nav-link-padding:                          10px 15px;
@nav-link-hover-bg:                         @gray-lighter;

@nav-disabled-link-color:                   @gray-light;
@nav-disabled-link-hover-color:             @gray-light;

@nav-open-link-hover-color:                 #fff;

//== Tabs
@nav-tabs-border-color:                     #ddd;

@nav-tabs-link-hover-border-color:          @gray-lighter;

@nav-tabs-active-link-hover-bg:             @body-bg;
@nav-tabs-active-link-hover-color:          @gray;
@nav-tabs-active-link-hover-border-color:   #ddd;

@nav-tabs-justified-link-border-color:            #ddd;
@nav-tabs-justified-active-link-border-color:     @body-bg;

//== Pills
@nav-pills-border-radius:                   @border-radius-base;
@nav-pills-active-link-hover-bg:            @component-active-bg;
@nav-pills-active-link-hover-color:         @component-active-color;


//== Pagination
//
//##

@pagination-color:                     @link-color;
@pagination-bg:                        #fff;
@pagination-border:                    #ddd;

@pagination-hover-color:               @link-hover-color;
@pagination-hover-bg:                  @gray-lighter;
@pagination-hover-border:              #ddd;

@pagination-active-color:              #fff;
@pagination-active-bg:                 @brand-primary;
@pagination-active-border:             @brand-primary;

@pagination-disabled-color:            @gray-light;
@pagination-disabled-bg:               #fff;
@pagination-disabled-border:           #ddd;


//== Pager
//
//##

@pager-bg:                             @pagination-bg;
@pager-border:                         @pagination-border;
@pager-border-radius:                  15px;

@pager-hover-bg:                       @pagination-hover-bg;

@pager-active-bg:                      @pagination-active-bg;
@pager-active-color:                   @pagination-active-color;

@pager-disabled-color:                 @pagination-disabled-color;


//== Jumbotron
//
//##

@jumbotron-padding:              30px;
@jumbotron-color:                inherit;
@jumbotron-bg:                   @gray-lighter;
@jumbotron-heading-color:        inherit;
@jumbotron-font-size:            ceil((@font-size-base * 1.5));


//== Form states and alerts
//
//## Define colors for form feedback states and, by default, alerts.

@state-success-text:             #3c763d;
@state-success-bg:               #dff0d8;
@state-success-border:           darken(spin(@state-success-bg, -10), 5%);

@state-info-text:                #31708f;
@state-info-bg:                  #d9edf7;
@state-info-border:              darken(spin(@state-info-bg, -10), 7%);

@state-warning-text:             #8a6d3b;
@state-warning-bg:               #fcf8e3;
@state-warning-border:           darken(spin(@state-warning-bg, -10), 5%);

@state-danger-text:              #a94442;
@state-danger-bg:                #f2dede;
@state-danger-border:            darken(spin(@state-danger-bg, -10), 5%);


//== Tooltips
//
//##

//** Tooltip max width
@tooltip-max-width:           200px;
//** Tooltip text color
@tooltip-color:               #fff;
//** Tooltip background color
@tooltip-bg:                  #000;
@tooltip-opacity:             .9;

//** Tooltip arrow width
@tooltip-arrow-width:         5px;
//** Tooltip arrow color
@tooltip-arrow-color:         @tooltip-bg;


//== Popovers
//
//##

//** Popover body background color
@popover-bg:                          #fff;
//** Popover maximum width
@popover-max-width:                   276px;
//** Popover border color
@popover-border-color:                rgba(0,0,0,.2);
//** Popover fallback border color
@popover-fallback-border-color:       #ccc;

//** Popover title background color
@popover-title-bg:                    darken(@popover-bg, 3%);

//** Popover arrow width
@popover-arrow-width:                 10px;
//** Popover arrow color
@popover-arrow-color:                 #fff;

//** Popover outer arrow width
@popover-arrow-outer-width:           (@popover-arrow-width + 1);
//** Popover outer arrow color
@popover-arrow-outer-color:           fadein(@popover-border-color, 5%);
//** Popover outer arrow fallback color
@popover-arrow-outer-fallback-color:  darken(@popover-fallback-border-color, 20%);


//== Labels
//
//##

//** Default label background color
@label-default-bg:            @gray-light;
//** Primary label background color
@label-primary-bg:            @brand-primary;
//** Success label background color
@label-success-bg:            @brand-success;
//** Info label background color
@label-info-bg:               @brand-info;
//** Warning label background color
@label-warning-bg:            @brand-warning;
//** Danger label background color
@label-danger-bg:             @brand-danger;

//** Default label text color
@label-color:                 #fff;
//** Default text color of a linked label
@label-link-hover-color:      #fff;


//== Modals
//
//##

//** Padding applied to the modal body
@modal-inner-padding:         15px;

//** Padding applied to the modal title
@modal-title-padding:         15px;
//** Modal title line-height
@modal-title-line-height:     @line-height-base;

//** Background color of modal content area
@modal-content-bg:                             #fff;
//** Modal content border color
@modal-content-border-color:                   rgba(0,0,0,.2);
//** Modal content border color **for IE8**
@modal-content-fallback-border-color:          #999;

//** Modal backdrop background color
@modal-backdrop-bg:           #000;
//** Modal backdrop opacity
@modal-backdrop-opacity:      .5;
//** Modal header border color
@modal-header-border-color:   #e5e5e5;
//** Modal footer border color
@modal-footer-border-color:   @modal-header-border-color;

@modal-lg:                    900px;
@modal-md:                    600px;
@modal-sm:                    300px;


//== Alerts
//
//## Define alert colors, border radius, and padding.

@alert-padding:               15px;
@alert-border-radius:         @border-radius-base;
@alert-link-font-weight:      bold;

@alert-success-bg:            @state-success-bg;
@alert-success-text:          @state-success-text;
@alert-success-border:        @state-success-border;

@alert-info-bg:               @state-info-bg;
@alert-info-text:             @state-info-text;
@alert-info-border:           @state-info-border;

@alert-warning-bg:            @state-warning-bg;
@alert-warning-text:          @state-warning-text;
@alert-warning-border:        @state-warning-border;

@alert-danger-bg:             @state-danger-bg;
@alert-danger-text:           @state-danger-text;
@alert-danger-border:         @state-danger-border;


//== Progress bars
//
//##

//** Background color of the whole progress component
@progress-bg:                 #f5f5f5;
//** Progress bar text color
@progress-bar-color:          #fff;

//** Default progress bar color
@progress-bar-bg:             @brand-primary;
//** Success progress bar color
@progress-bar-success-bg:     @brand-success;
//** Warning progress bar color
@progress-bar-warning-bg:     @brand-warning;
//** Danger progress bar color
@progress-bar-danger-bg:      @brand-danger;
//** Info progress bar color
@progress-bar-info-bg:        @brand-info;


//== List group
//
//##

//** Background color on `.list-group-item`
@list-group-bg:                 #fff;
//** `.list-group-item` border color
@list-group-border:             #ddd;
//** List group border radius
@list-group-border-radius:      @border-radius-base;

//** Background color of single list items on hover
@list-group-hover-bg:           #f5f5f5;
//** Text color of active list items
@list-group-active-color:       @component-active-color;
//** Background color of active list items
@list-group-active-bg:          @component-active-bg;
//** Border color of active list elements
@list-group-active-border:      @list-group-active-bg;
//** Text color for content within active list items
@list-group-active-text-color:  lighten(@list-group-active-bg, 40%);

//** Text color of disabled list items
@list-group-disabled-color:      @gray-light;
//** Background color of disabled list items
@list-group-disabled-bg:         @gray-lighter;
//** Text color for content within disabled list items
@list-group-disabled-text-color: @list-group-disabled-color;

@list-group-link-color:         #555;
@list-group-link-hover-color:   @list-group-link-color;
@list-group-link-heading-color: #333;


//== Panels
//
//##

@panel-bg:                    #fff;
@panel-body-padding:          15px;
@panel-heading-padding:       10px 15px;
@panel-footer-padding:        @panel-heading-padding;
@panel-border-radius:         @border-radius-base;

//** Border color for elements within panels
@panel-inner-border:          #ddd;
@panel-footer-bg:             #f5f5f5;

@panel-default-text:          @gray-dark;
@panel-default-border:        #ddd;
@panel-default-heading-bg:    #f5f5f5;

@panel-primary-text:          #fff;
@panel-primary-border:        @brand-primary;
@panel-primary-heading-bg:    @brand-primary;

@panel-success-text:          @state-success-text;
@panel-success-border:        @state-success-border;
@panel-success-heading-bg:    @state-success-bg;

@panel-info-text:             @state-info-text;
@panel-info-border:           @state-info-border;
@panel-info-heading-bg:       @state-info-bg;

@panel-warning-text:          @state-warning-text;
@panel-warning-border:        @state-warning-border;
@panel-warning-heading-bg:    @state-warning-bg;

@panel-danger-text:           @state-danger-text;
@panel-danger-border:         @state-danger-border;
@panel-danger-heading-bg:     @state-danger-bg;


//== Thumbnails
//
//##

//** Padding around the thumbnail image
@thumbnail-padding:           4px;
//** Thumbnail background color
@thumbnail-bg:                @body-bg;
//** Thumbnail border color
@thumbnail-border:            #ddd;
//** Thumbnail border radius
@thumbnail-border-radius:     @border-radius-base;

//** Custom text color for thumbnail captions
@thumbnail-caption-color:     @text-color;
//** Padding around the thumbnail caption
@thumbnail-caption-padding:   9px;


//== Wells
//
//##

@well-bg:                     #f5f5f5;
@well-border:                 darken(@well-bg, 7%);


//== Badges
//
//##

@badge-color:                 #fff;
//** Linked badge text color on hover
@badge-link-hover-color:      #fff;
@badge-bg:                    @gray-light;

//** Badge text color in active nav link
@badge-active-color:          @link-color;
//** Badge background color in active nav link
@badge-active-bg:             #fff;

@badge-font-weight:           bold;
@badge-line-height:           1;
@badge-border-radius:         10px;


//== Breadcrumbs
//
//##

@breadcrumb-padding-vertical:   8px;
@breadcrumb-padding-horizontal: 15px;
//** Breadcrumb background color
@breadcrumb-bg:                 #f5f5f5;
//** Breadcrumb text color
@breadcrumb-color:              #ccc;
//** Text color of current page in the breadcrumb
@breadcrumb-active-color:       @gray-light;
//** Textual separator for between breadcrumb elements
@breadcrumb-separator:          "/";


//== Carousel
//
//##

@carousel-text-shadow:                        0 1px 2px rgba(0,0,0,.6);

@carousel-control-color:                      #fff;
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	R�sum� des caract�ristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim� | JNP Sri Lanka | National Freedom Front
		




	
	
			
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	
	






































		
		

		  

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R�sum� des caract�ristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim�

																	
by JNP Media   15/08/2024 | 4:17
                                    0
                                    Posted in steroid 

															

							

																			R�sum� des caract�ristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim�
																		

							

																
R�sum� des caract�ristiques du produit TAMOXIFENE VIATRIS 20 mg, comprim�


Il s’utilise en association avec d’autres médicaments pour traiter un cancer du sein au stade précoce. Il sert également à traiter le cancer du sein qui a atteint un stade avancé ou qui s’est propagé à d’autres parties du corps. Entre les différents anti-aromatases, les chercheurs observent peu de différence d’efficacité. Avec l’anastrozole, le taux de survie sans récidive après 5 ans est de 90%, de 88% avec l’exémestane, et de 89,4% avec le létrozole.


    

  • L’épaisseur endométriale des patientes sous raloxifène n’était pas différente de celle des patientes sous placebo.
    • 

  • Informez votre médecin si vous prenez par ailleurs des anticoagulants oraux.
    • 

  • Des données suggèrent que le récepteur aux oestrogènes peut réguler l’expression génique par au moins deux voies distinctes qui sont spécifiques au ligand, au tissu et/ou au gène.
    • 



Effets secondaires du tamoxifène


Une prise en charge spécialisée en oncologie, par exemple dans un centre de santé intégrative, avec un parcours de soin adapté peut permettre de diminuer tous ces effets indésirables, d’améliorer la qualité de vie et de maintenir une bonne observance du traitement. Cet évènement indésirable était plus fréquent au cours des six premiers mois de traitement et survenait rarement de novo après cette période. https://theroyalpets.com/steroid-68/steroides-pour-la-musculation-un-guide-approfondi/ Le statut du polymorphisme CYP2D6 peut être associé à une variabilité de la réponse clinique au tamoxifène. Les donn�es cliniques disponibles sugg�rent que les patients qui sont homozygotes pour les all�les CYP2D6 non-fonctionnelles, peuvent pr�senter une diminution de l’effet du tamoxif�ne dans le traitement du cancer du sein. Les �tudes disponibles ont principalement �t� r�alis�es chez des femmes m�nopaus�es (voir les rubriques 4.4 et 5.2). Comme pour tous les traitements, l’hormonothérapie peut induire des effets secondaires.


Prendre RDV


Environ échographies transvaginales (ETV) ont été évaluées chez 831 patientes, tous groupes confondus. L’épaisseur endométriale des patientes sous raloxifène n’était pas différente de celle des patientes sous placebo. Après 3 ans de traitement, une augmentation de l’épaisseur endométriale d’au moins 5 mm évaluée par échographie transvaginale, a été observée chez 1,9 % des 211 femmes traitées par raloxifène 60 mg/jour en comparaison aux 1,8 % des 219 femmes sous placebo.


Beipackzettel von TAMOXIFEN-ratiopharm 20 mg Tabletten


Le tamoxif�ne est principalement m�tabolis� par le CYP3A4 en N-desm�thyl-tamoxif�ne, qui est ensuite m�tabolis� par le CYP2D6 en un autre m�tabolite actif l’endoxif�ne. Chez les patientes qui n’ont pas l’enzyme CYP2D6, les concentrations d’endoxif�ne sont inf�rieures d’approximativement 75 % en comparaison aux patientes ayant une activit� CYP2D6 normale. L’administration d’inhibiteurs puissants du CYP2D6 r�duit les taux d’endoxif�ne circulant � un niveau similaire. Chez les patients pr�sentant un angi�d�me h�r�ditaire, le tamoxif�ne peut provoquer ou aggraver les sympt�mes d�angi�d�me. Le raloxifène et les oestrogènes ont un effet similaire sur le remodelage osseux et sur le métabolisme calcique. Le raloxifène est associé à une réduction de la résorption osseuse et à un déplacement positif de la valeur moyenne de la balance calcique de 60 mg par jour, dû principalement à une diminution des pertes calciques urinaires.


Si cela vous intéresse, vous pouvez consulter la fiche du tamoxifène sur le site de la Haute Autorité de Santé. Il faut conserver les comprimés dans leur emballage d’origine, à température ambiante, hors de portée des enfants et animaux domestiques. Anomalie de la numération formule sanguine, augmentation des transaminases.

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